Liposomal Melatonin for High Quality Sleep

Each capsule contains 10 mg of Liposomal Melatonin. Free from artificial additives, preservatives, soy, GMOs, and gluten, made to deliver a clean, targeted melatonin supplement for sleep.

Every Ingredient Has Its Purpose

• Liposomal Melatonin 10 mg: The sleep hormone naturally produced by your body. The lipid-based form helps improve delivery into systemic circulation compared to standard tablets.
• Phospholipids: These form the delivery structure. Similar to biological membranes, they help enhance compatibility and transport across the digestive system.
• Tricalcium Phosphate: Maintains structural stability and ensures consistent dosing.
• Hydroxy Propyl Methyl Cellulose (HPMC): Plant-derived vegan capsule shell that preserves the integrity of the formulation.

Liposomal Benefits

• Higher early plasma levels: Up to 4.6× higher melatonin levels within 5 minutes compared to a standard tablet (lipid-based delivery study)
• Reduced first-pass metabolism: Helps protect melatonin from significant breakdown in the liver
• Improved delivery efficiency: Lipid-based structure enhances absorption compared to standard oral tablets
• Precision manufacturing: Produced at a WHO-GMP certified Eskag Pharma facility with controlled particle size for consistency

Melatonin Benefits

• Faster sleep onset: Reduces time to fall asleep from ~18.1 minutes to ~10.8 minutes (~40% improvement in study conditions)
• Supports circadian rhythm: Helps regulate your internal sleep-wake cycle
• Sustained activity: With ~93-minute half-life vs ~48 minutes in standard forms, supports longer sleep duration
• Jet lag & shift work support: Helps reset disrupted sleep cycles

How to Take:

Take one capsule 30-60 minutes before bedtime with water, preferably on an empty stomach. Use consistently for best results.

Case Study on Liposomal Melatonin's Efficacy

Research shows that liposomal melatonin is absorbed far more effectively than conventional melatonin capsules, reaching the bloodstream faster and working at meaningfully lower doses.

• 40% reduction in time to fall asleep, from 18.1 minutes down to 10.8 minutes, in a 100-person double-blind RCT (p = 0.002).
• 4.6× higher melatonin levels within the first 5 minutes compared to a standard tablet.
• ~2× longer active duration; half-life of 93 minutes’ vs 48 minutes, so it supports sleep through the night, not just at the start.

Data based on lipid-based delivery systems, including emulsion and nanoparticle formulations.

References:

1. Bonuccelli, A., Santangelo, A., Castelli, F., Giulia Magherini, Volpi, E., Costa, E., Alesci, E., Massimetti, G., Francesca Felicia Operto, Diego Giampiero Peroni and Orsini, A. (2022). Efficacy of Liposomal Melatonin in sleep EEG in Childhood: A Double Blind Case Control Study. International Journal of Environmental Research and Public Health, 20(1), pp.552–552.
2. Priano, L., Esposti, D., Esposti, R., Castagna, G., C. De Medici, F. Fraschini, Maria Rosa Gasco and Mauro, A. (2007). Solid Lipid Nanoparticles Incorporating Melatonin as New Model for Sustained Oral and Transdermal Delivery Systems. Journal of Nanoscience and Nanotechnology, 7(10), pp.3596–3601.
3. Bartoli, A.N. (2013). Bioavailability of a New Oral Spray Melatonin Emulsion Compared with a Standard Oral Formulation in Healthy Volunteers. Journal of Bioequivalence & Bioavailability, 04(07).

What are Liposomal Melatonin Capsules?

Cellular Prime Liposomal Melatonin capsules are designed to improve how melatonin is delivered in your body. Lipid-based technology surrounds melatonin in a phospholipid structure, helping enhance absorption compared to standard tablets.

How to Choose the Right Melatonin Capsules

Most melatonin supplements use standard tablets, where a large portion of the dose is lost during digestion and liver metabolism before reaching circulation.

When choosing a supplement, consider:

• Lipid-based Delivery: Supports improved absorption compared to standard tablets
• Pharmaceutical-grade Manufacturing: Produced at Eskag Pharma, a WHO-GMP, FSSAI, ISO 9001:2015, and GLP-certified facility
• Raw Material Integrity: Manufactured using materials from WBCIL, a WHO-GMP certified facility

View Cellular Prime’s Quality Control

Who Should Take Liposomal Melatonin

• Trouble falling asleep: For those who lie awake for 20+ minutes before drifting off.
• Groggy after regular melatonin: Ideal for those who find standard melatonin tablets too heavy the next morning.
• Frequent travellers: Clinically recognised for resetting circadian rhythm after jet lag.
• Shift workers: Helps re-establish sleep patterns disrupted by irregular schedules.
• Age 30+: Natural melatonin production declines with age; supplementation supports what the body no longer makes efficiently.